Combined Penicillin and Chemotherapy in Acute Gonorrheal Urethritis
نویسنده
چکیده
A synergistic action between penicillin and chemotherapy when used concomitantly has been shown experimentally3 to exist. Evidence is accumulating which tends to demonstrate that these drugs also have a synergistic action clinically in the treatment of acute gonorrheal urethritis. Oard et al.2 have written of striking results in the treatment of 70 cases in young white males using 12 gm. of sulfathiazole in combination with 50,000 units of penicillin, with only 6 failures, a rate of 91.43 per cent cures. All of the failures were cured by an additional course of 100,000 units of penicillin. Our experience at this dispensary on the southern coast of England supports their results. A combined use of penicillin and chemotherapy is not only indicated from the standpoint of the synergistic action of the two drugs, but it is known that certain cases are chemoresistant and others are penicillin-resistant. The method of combined therapy will eliminate most of the failures resulting from the selection of the wrong drug in the initial treatment of these cases. During the period Dec. 15, 1944, to July 1, 1945, 159 cases of acute gonorrheal urethritis in young white males were treated by various methods at this dispensary. A combination of penicillin and sulfathiazole was employed in 105 of these cases. No cases which had a history of chronic disease or had been treated prior to admission are included in this study. The colored patients are not included because they were of insufficient number to be statistically significant. Our impression that they respond to treatment more readily than do white patients is in accord with the experience of others. The overwhelming majority of patients were from amphibious craft afloat, which, lacking a medical officer, referred their
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 18 شماره
صفحات -
تاریخ انتشار 1945